Influenza A Virus Matrix Protein 1-Specific Human CD8+ T-Cell Response Induced in Trivalent Inactivated Vaccine Recipients ▿
Identifieur interne : 001244 ( Main/Exploration ); précédent : 001243; suivant : 001245Influenza A Virus Matrix Protein 1-Specific Human CD8+ T-Cell Response Induced in Trivalent Inactivated Vaccine Recipients ▿
Auteurs : Masanori Terajima [États-Unis] ; John Cruz [États-Unis] ; Anita M. Leporati [États-Unis] ; Laura Orphin [États-Unis] ; Jenny Aurielle B. Babon [États-Unis] ; Mary Dawn T. Co [États-Unis] ; Pamela Pazoles [États-Unis] ; Julie Jameson [États-Unis] ; Francis A. Ennis [États-Unis]Source :
- Journal of Virology [ 0022-538X ] ; 2008.
Abstract
Among 17 HLA-A2-positive healthy adults, CD8+ T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals. The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8+ T-cell line for specific lysis. These data show that TIV, which is formulated to contain surface glycoproteins to induce serotype-specific antibody responses, also contains M1, capable of inducing subtype cross-reactive CD8+ T-cell responses in some vaccinees.
Url:
DOI: 10.1128/JVI.01047-08
PubMed: 18614638
PubMed Central: 2546892
Affiliations:
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Babon</name><affiliation wicri:level="2"><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. 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Ennis</name><affiliation wicri:level="2"><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Among 17 HLA-A2-positive healthy adults, CD8<sup>+</sup> T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals. The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8<sup>+</sup> T-cell line for specific lysis. These data show that TIV, which is formulated to contain surface glycoproteins to induce serotype-specific antibody responses, also contains M1, capable of inducing subtype cross-reactive CD8<sup>+</sup> T-cell responses in some vaccinees.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name></region><name sortKey="Babon, Jenny Aurielle B" sort="Babon, Jenny Aurielle B" uniqKey="Babon J" first="Jenny Aurielle B." last="Babon">Jenny Aurielle B. Babon</name><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name><name sortKey="Jameson, Julie" sort="Jameson, Julie" uniqKey="Jameson J" first="Julie" last="Jameson">Julie Jameson</name><name sortKey="Leporati, Anita M" sort="Leporati, Anita M" uniqKey="Leporati A" first="Anita M." last="Leporati">Anita M. Leporati</name><name sortKey="Orphin, Laura" sort="Orphin, Laura" uniqKey="Orphin L" first="Laura" last="Orphin">Laura Orphin</name><name sortKey="Pazoles, Pamela" sort="Pazoles, Pamela" uniqKey="Pazoles P" first="Pamela" last="Pazoles">Pamela Pazoles</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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